The metabolism of cell growth: aerobic glycolysis

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.

Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells. Although it has been established that defects in mitochondrial respiration are not the cause of cancer or aerobic glycolysis, the advantages of enhanced glycolysis in cancer remain controversial. Many...

Aerobic Glycolysis: Beyond Proliferation

Aerobic glycolysis has been generally associated with cancer cell proliferation, but fascinating and novel data show that it is also coupled to a series of further cellular functions. In this Mini Review, we will discuss some recent findings to illustrate newly defined roles for this process, in particular in non-malignant cells, supporting the idea that metabolism can be considered as an integ...

Rewiring of glycolysis in cancer cell metabolism.

Altered metabolism constitutes a nearly universal feature of cancer cells. This metabolic reorganization in part originates from the high proliferative state displayed by cancer cells. The nature of this altered metabolism is complex with multiple strategies implemented across diverse contextual dependencies to enable the accumulation of the biomass that is necessary for proliferation in a stre...

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline biosynthesis (PB) from glutamine. Here we show MYC increases the expression of the enzymes in PB at both protein and mRNA levels. Blockade of PB decreases tumor cell growth and energy production. Addition of Δ(1)-pyrroline-5-carboxylate (P5C) or pro...